The uterine cervix comprises an ectocervix and an endocervix with a transition zone that undergoes squamous and glandular metaplasia during the menstrual cycle fig. Clinical significance of squamous metaplasia in the cervix in the cervix, the area of the epithelium that has undergone metaplastic change is called the transformation zone tz. Young woman with postconization hematometra due to endocervical bone metaplasia j low genit tract dis 2014. The replacement cells are similar to the cells that create the lining of. Even though sebaceous metaplasia is exceedingly rare, it was reported in the cervix as early as 1969.
Squamous metaplasia of normal and carcinoma in situ of hpv 16. The metaplastic process of the cervix starts with the appearance of subcolumnar reserve cells of the endocervical epithelium. Common sites for squamous metaplasia include the bladder and cervix. There is squamous metaplasia of the endometrium with cellular debris in the uterine lumen and a few associated inflammatory cells. Om affecting the cervix alone is a more rare condition that has. Numerous studies have shown that highgrade cin primarily involves the immature metaplastic epithelial cells of the tz where most, if not all cervical cancers arise. Uterus, endometrium metaplasia, squamous nonneoplastic. The inward and outward migration of the squamocolumnar junction is important to pathologic changes in the cervix related to hpv infection and cancer see below.
Todos os casos estavam associados a varios outros diagnosticos morfologios, neoplasicos ou naoneoplasicos. It is a physiological condition a metaplasia is defined as the change of one type of epithelium to another type of epithelium. Aug 01, 1992 the importance of cervical squamous metaplasia and human papillomavirus 16 hpv 16 infection for cervical carcinoma has been well established. However, the transformation zone of metaplastic change within the cervix is very vulnerable to human papilloma virus infection, which is. An example of physiologic metaplasia is the squamous metaplasia that occurs in the uterine cervix during the menstrual cycle as the squamocolumnar junction migrates across the transformation zone fig. The change from one type of cell to another may be part of a normal maturation process, or caused by some sort of abnormal stimulus. A metaplasia is defined as the change of one type of epithelium to another type of epithelium. Squamous metaplasia is a benign noncancerous change metaplasia of surfacing lining cells epithelium to a squamous morphology. Pdf osseous metaplasia of the cervix and endometrium. Nov 04, 20 pap smear and it came back with hsil then biopsy which came back cervix uteriuterine cervix squamous metaplasia epidermioid metepidermailzation. To report a case of osseous metaplasia of the cervix and endometrium as a. Squamous metaplasia of the uterine cervix libre pathology. The transformation of nonosseous soft tissue into bone is known as osseous metaplasia om.
Squamous metaplasia of the uterine cervix is a common change of the uterine cervix that may resemble squamous intraepithelial lesion. Squamous metaplasia 16 metaplasia is a nonneoplastic transformation of one mature cell type to another mature cell type that is not normally present at that location. The cervix is the lower part of the uterus, the place where a baby grows during pregnancy. This pathology is frequent in women after 50 years, although it happens even earlier. A rare transformation article pdf available in journal of the turkish german gynecology association 161. Squamous metaplasia of uterine cervix is a benign condition and there is no risk for a malignant transformation. We are presenting a case of osseous metaplasia of the cervix which is a rare pathological transformation. Metaplasia of the cervix is one of the precancerous diseases, which has serious consequences, in the absence of treatment or incorrect diagnostic and therapeutic tactics.
Ultima revision 1212020 version en ingles revisada por. Metaplasia can also occur as a normal physiologic response. Glandular metaplasia an overview sciencedirect topics. Metaplasia is a reaction of the exposed everted columnar epithelium ectropion to irritation by acidic vaginal environment.
This condition most commonly affects the musculoskeletal and central nervous systems and it is a wellknown phenomenon in different soft tissue organs. Intestinal metaplasia is a condition in which the cells that create the lining of your stomach are changed or replaced. Squamous metaplasia of uterine cervix is a common, benign condition, wherein the glandular epithelium of cervix changes into squamous epithelium of cervix. Metaplastic change in the cervix and its physiological basis. E19 44 year old woman with ectocervical epidermoid metaplasia arch pathol lab med 2004. Pdf novel management of endometrial osseous metaplasia open. Smokers often exhibit squamous metaplasia in the linings of their airways. Metaplasia definition of metaplasia by medical dictionary. In cervical smears, tuboendometrioid metaplastic changes may be. Metaplastic change in the cervix and its physiological. Nov 25, 2015 uterus, endometrium metaplasia, squamous in a female sprague dawley rat from a chronic study higher magnification of figure 1.